If you should lose a major amount of weight then couple train with a minimize down on fatty meals, portion management use and eat 3 balanced meals a day. The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and that are structurally not associated to SET-area proteins four - 6 Recent work suggests that SET-domain-containing proteins methylate just a few proteins in addition to histones (see later)