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They discovered that no normal cerevisiae or carlsbergensis strains utilised lysine whereas many other yeasts, together with wild yeasts, did so.

Later, Morris & Eddy1 described a stable lysine medium for the isolation and enumeration of wild yeasts in pitching yeast. A simple little thing like that tells you that in the event you're attempting to withstand consuming, the subtlest things can mess you up. The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and which are structurally not related to SET-area proteins four - 6 Recent work means that SET-domain-containing proteins methylate a number of proteins along with histones (see later)