Ipamorelin and CJC-1295 are often paired in a peptide protocol that many bodybuilders, athletes and anti-aging enthusiasts use to boost growth hormone release while supporting recovery and muscle growth. The combination delivers two complementary mechanisms: ipamorelin is a selective ghrelin receptor agonist that signals the pituitary gland to secrete growth hormone, whereas CJC-1295 (also known as Tesamorelin when used clinically) is an analog of growth hormone-releasing hormone (GHRH) with an extended half-life thanks to its hexapeptide attachment. Together they produce a more sustained and potent increase in circulating growth hormone than either peptide alone, making the duo popular for improving body composition, reducing fat mass, enhancing strength training adaptations, and speeding post-exercise recovery.

Ipamorelin + CJC-1295: Peptide Combo Explained For valley Growth And Recovery

The protocol usually involves subcutaneous injections taken twice daily, often at 7 a.m. and 6 p.m., with a typical dose of 100 µg ipamorelin and 200 µg CJC-1295 per injection. The timing mimics the body’s natural growth hormone secretion pattern—an early morning surge followed by a late-evening rise—thereby maximizing anabolic effects while minimizing potential side-effects such as excessive appetite or water retention that can occur with less selective peptides.

Because ipamorelin specifically stimulates ghrelin receptors without significantly raising cortisol, users often report minimal changes in hunger levels compared to other growth hormone secretagogues. CJC-1295’s longer half-life (up to 24 hours) reduces the need for frequent injections